Holders RS Berkane were drawn into Group B with Algeria's JS Kabylie, Coton Sport of Cameroon and Zambian debutants NAPSA Stars.
In group D, Raja will be accompanied with Pyramids FC (Egypt), Nkana FC (Zambia) and the winner of the game between Namungo FC (Tanzania) and Primeiro de Agosto (Angola).
The composition of the groups is as follows:
- Group A
Enyimba FC (Nigeria)
ES Setif (Algeria)
Orlando Pirates (South Africa)
Ahli Benghazi (Libya)
- Group B
RS Berkane (Morocco)
JS Kabylie (Algeria)
Coton Sport (Cameroon)
NAPSA Stars (Zambia)
- Group C
Etoile du Sahel (Tunisia) / Young Buffaloes (Eswatini)
CS Sfaxien (Tunisia)
Salitas FC (Burkina Faso)
ASC Les Jaraaf (Senegal)
- Group D
Raja (Morocco)
Pyramids FC (Egypt)
Nkana FC (Zambia)
Namungo FC (Tanzania) / Primeiro de Agosto (Angola).